If you accidentally took two Nurtec (rimegepant) tablets within 24 hours, you're over the label's limit of one 75 mg tablet per 24 hours. The leaflet's advice for taking too much: go to the nearest ER right away. You can also call Poison Help at 1-800-222-1222 (1-844-764-7669 in Canada).
Two tablets is 150 mg. The Pfizer prescribing information on DailyMed says "There is limited clinical experience with NURTEC ODT overdosage." Bigger doses were tested in supervised volunteer studies. That is not a promise about you.
This article provides general information about medication management and is not a substitute for professional medical advice. Consult your doctor or pharmacist for advice specific to your medications.
What to Do If You Accidentally Took Two Nurtec
- Follow the leaflet. The FDA-approved Patient Information for Nurtec says: "If you take too much NURTEC ODT, go to the nearest emergency room right away."
- Call Poison Help at 1-800-222-1222. MedlinePlus says to call "right away" if you suspect a poisoning. In Canada, call 1-844-764-7669, or 1-800-463-5060 in Quebec (Health Canada).
- Get emergency help for allergy signs. The leaflet says to call your healthcare provider or get emergency help right away for swelling of the face, mouth, tongue or throat, trouble breathing, or rash. It warns that a reaction "can happen days after you take NURTEC ODT." Canada's leaflet adds: "stop taking NURTEC ODT and get immediate medical help." Call 911 if breathing is hard.
- Have the blister pack and your medicine list ready. Say what time you took each tablet, and mention any medicine on the label's 48-hour list (below).
- Ask your prescriber or pharmacist before your next tablet.
Not sure you took it twice at all? See what to do when you can't remember if you took your medication. For other drugs, see taking medication twice by mistake.
Can You Take Nurtec More Than Once a Day?
No. The Patient Information says: "You should not take more than 1 tablet in 24 hours." The prescribing information sets "The maximum dose in a 24-hour period" at 75 mg.
Some migraine medicines work differently. The Ubrelvy (ubrogepant) label says "If needed, a second dose may be taken at least 2 hours after the initial dose." If you've used Ubrelvy, don't carry that rule over to Nurtec. Sumatriptan has its own second-dose rule, too.
There is also a monthly line: "It is not known if it is safe to take more than 18 doses of NURTEC ODT in 30 days."
A Canadian leaflet reads differently. Canada's product monograph lists Nurtec for acute treatment, at a maximum of 75 mg per day. It says the safety of more than 15 doses in 30 days has not been established. Follow the leaflet that came with your tablets, and ask your pharmacist if something doesn't match.
What Happens If You Take 2 Nurtec? What the Studies Tested
The label's overdose section says treatment "should consist of general supportive measures including monitoring of vital signs." There is no specific antidote, and rimegepant is "unlikely to be significantly removed by dialysis."
The label also says that at "a single dose 4 times the recommended dose, rimegepant does not prolong the QT interval to any clinically relevant extent." (QT is a heart-rhythm measure.) That doesn't mean nothing happened. In the heart-rhythm study, headache was the most common side effect possibly linked to the drug: 1 person after 75 mg, 4 people after 300 mg.
A 2023 study went much higher. Healthy adults aged 18 to 55 got single doses from 25 to 1,500 mg, or up to 600 mg a day for 14 days, as a capsule form of rimegepant. The authors called it "safe and generally well tolerated" in that study. They also found blood levels rose faster than the dose did.
Canada's monograph adds one line next to the same "limited clinical experience" wording: "No overdose symptoms have been reported."
The label puts rimegepant's half-life (the time for blood levels to drop by half) at about 11 hours. The studies can't tell you how a second tablet works with your other medicines or your liver. The label says to avoid Nurtec in severe liver impairment, where one tablet gave about 2 times the usual blood levels.
Nausea After Two Nurtec: Is It the Medicine or the Migraine?
Nausea was the most common side effect in the acute-treatment trial (2% on Nurtec vs 0.4% on placebo). It's also a migraine symptom. In that trial, 28% of patients who picked a "most bothersome symptom" chose nausea. Nurtec's site lists nausea and vomiting among early migraine signs.
Some label warnings are not about "too much" at all and can follow any dose:
- An allergic reaction, which can happen days later.
- New or worse high blood pressure, most often reported within 7 days of starting.
- Raynaud's phenomenon, where fingers or toes feel numb, cool or painful, or turn pale, blue, then red. The label's counseling section says to stop Nurtec and call your provider if this happens.
Tell Poison Help or your doctor every symptom, even ones that feel like "just the migraine."
Accidentally Took Nurtec Two Days in a Row?
If you use it as needed for attacks: the label's limit is one tablet per 24-hour period, plus the 18-in-30-days line, so hours matter more than dates. A 9 pm tablet and a 7 am tablet the next morning fall on different days. They're only 10 hours apart, so the second one breaks the 24-hour limit. Ask your pharmacist to check your times.
If you take certain other medicines, the window is 48 hours. The label says to "Avoid another dose of NURTEC ODT within 48 hours" with moderate CYP3A4 inhibitors or potent P-gp inhibitors. Both kinds of drugs can raise rimegepant levels.
The US label names amiodarone, cyclosporine, lapatinib, quinidine and ranolazine (P-gp) and fluconazole (moderate CYP3A4). Canada's monograph adds diltiazem and erythromycin (moderate CYP3A4) and verapamil (P-gp). On one of these 48-hour drugs, two days in a row falls inside that window.
Strong CYP3A4 inhibitors, such as itraconazole, are stricter: the label says to avoid Nurtec with them at all. Either way, call your pharmacist or Poison Help, and don't stop the other medicine on your own. Our spacing guide covers other medicines that need hours between them.
If you take it every other day for prevention: two days in a row breaks your schedule. The label does not say what to do after a dose on the wrong day. Ask your prescriber. One way it happens: the manufacturer suggests remembering "even or odd numbered days," but to "adjust based on the numbers of days in each month." In a 31-day month, the 31st and the 1st are both odd. Our reset guide has questions to bring to that call.
Nurtec Every Other Day: What If a Migraine Hits on an Off Day or a Dose Day?
The label gives the as-needed dose and the every-other-day dose separately. It does not say whether someone on the every-other-day plan can take a tablet for an attack on an off day. The answers below come from studies, so treat them as questions for your prescriber, not permission.
In a 52-week study of 603 people, everyone took one tablet every other day. For an attack, they "could take one tablet of rimegepant 75 mg on non-scheduled dosing days." The cap was "a maximum of one rimegepant 75 mg tablet per calendar day." No medication-overuse headache was reported in that study. A 12-week group of 286 people followed the same plan.
| Situation | What the label says | What the studies did | Ask your prescriber |
|---|---|---|---|
| Migraine on an off day | 1 tablet in 24 hours; no rule for combining the schedules | One tablet allowed that day | Whether you can, and how to count 24 hours |
| Migraine on a dose day | Maximum 75 mg in 24 hours | Still one tablet that day | Whether to take your scheduled tablet when the attack starts |
| Another medicine for the attack | Lists what the 12-week trial allowed | 12-week trial: triptans, NSAIDs, acetaminophen, nausea medicines, muscle relaxants, aspirin. 52-week study: no triptans. Neither allowed other CGRP migraine drugs | Your rescue plan |
| Tablets per month | Acute-use section: safety above 18 doses in 30 days not established | Average 14.6 a month | Whether your count is OK |
Table sources: Pfizer prescribing information, the 52-week study, and the trial registry.
One catch: the studies counted calendar days, but your label counts 24 hours. A 10 pm dose-day tablet and an 8 am off-day tablet sit on different calendar days but only 10 hours apart, so the second breaks the label's 24-hour limit.
How Pillo Helps Keep an Every-Other-Day Schedule Straight
The manufacturer suggests phone or calendar reminders for every-other-day dosing. Pillo can set a tablet for every other day with Complex Schedule Support. The persistent alarm won't stop until you acknowledge it, and your dose history shows whether today's tablet was already logged before you reach for another.
Dose Spacing Alerts flag two doses scheduled too close together. That's a scheduling aid, not a safety check, so 24-hour and 48-hour questions still go to your pharmacist. Pillo is free for unlimited medications, with ads.
Frequently Asked Questions
How many hours between Nurtec doses?
For attacks, 24 hours: the Nurtec label allows one 75 mg tablet in 24 hours. It's 48 hours between doses if you also take certain drugs such as fluconazole or cyclosporine. For prevention, it's one tablet every other day.
What if I took 2 Nurtec in one day, or within an hour?
Either way, that's over the label's limit of one tablet in 24 hours. The leaflet says to go to the nearest emergency room right away if you take too much. Poison Help (1-800-222-1222, or 1-844-764-7669 in Canada) can also talk you through it.
What if a child swallowed a Nurtec tablet?
Call Poison Help at 1-800-222-1222 right away, or 1-844-764-7669 in Canada, and call 911 for trouble breathing. The US leaflet says "It is not known if NURTEC ODT is safe and effective in children." Canada's monograph says to call "immediately, even if there are no signs or symptoms."
What if I miss my every-other-day Nurtec dose?
The US label does not say what to do after a missed every-other-day dose, so call your prescriber or pharmacist. Taking two at once to catch up would go over the label's one-tablet-in-24-hours limit.
How long does Nurtec stay in your system?
Rimegepant's half-life is about 11 hours in healthy adults, according to the label. A study of single doses up to 1,500 mg found a median half-life of 8 to 12 hours.
Is it safe to take Nurtec every day?
That one is your prescriber's call. For attacks, the label allows up to one tablet a day as needed and says the safety of more than 18 doses in 30 days "has not been established." The 52-week study allowed up to one tablet per calendar day.
This article is for informational purposes only and does not constitute medical advice. If you think you or someone else took too much Nurtec, call Poison Help at 1-800-222-1222 (1-844-764-7669 in Canada), or 911 in an emergency.
Sources
- Nurtec ODT (rimegepant) prescribing information and Patient Information, Pfizer, on DailyMed
- Ubrelvy (ubrogepant) prescribing information, on DailyMed
- Nurtec ODT product monograph, Pfizer Canada (Health Canada Drug Product Database)
- Kudrow D, et al. A 52-week open-label extension study of oral rimegepant for the preventive treatment of migraine. Headache, 2025
- Croop R, et al. A multicenter, open-label long-term safety study of rimegepant for the acute treatment of migraine. Cephalalgia, 2024
- Bertz R, et al. Single and multiple dose study of rimegepant in healthy participants. Cephalalgia, 2023
- Bhardwaj R, et al. Randomized TQT study of single therapeutic/supratherapeutic rimegepant doses in healthy adults. Clinical and Translational Science, 2024
- ClinicalTrials.gov NCT03732638: rimegepant in migraine prevention
- How to Take Nurtec ODT, Pfizer
- MedlinePlus: Poisoning
- America's Poison Centers: Poison Help
- Health Canada: 1-844 POISON-X
